Theophylact of Ohrid

"And hearing this," he says, "His relatives" — perhaps people from the same hometown as Him, or even His brothers — "went out to take hold of Him; for they said that He was out of His mind," that is, that He had a demon. Since they heard that He was casting out demons and healing diseases, out of envy they thought that He had a demon and "was out of His mind," which is why they wanted to seize Him, so as to bind Him as one possessed. This is what His relatives thought and intended to do with Him.

Commentary on Mark ↗

Bede

And again the crowd gathered, so much so that they could not even eat bread. Oh, how happy is the occupation of the Savior, how blessed is the multitude of the gathering crowd, to whom there was so much eagerness to hear the word of God, so much care to obtain salvation, that to the author of salvation and to those who were with Him, not even the hour of eating remained free from the solace of imparting life to the needy! …

On the Gospel of Mark ↗