Cyril of Alexandria

Or He says this, because before that Jerusalem should be taken by the Romans, the disciples, having suffered persecution from the Jews, were imprisoned and brought before rulers; Paul was sent to Rome to Cæsar, and stood before Festus and Agrippa.

Catena Aurea by Aquinas ↗

Theophylact of Ohrid

"Before... all these things" that are to happen at the end of the world, or also at the captivity (for, as I said, He joins the discourse about the end with the discourse about the captivity), "they shall lay hands on you," that is, My disciples. And indeed, before the captivity of Jerusalem the apostles were driven out of it, by a special providence of God, namely: so that all the horrors would fall only upon the crucifiers, while they, that is the apostles, would fill the whole world with preaching. …

Commentary on Luke ↗

Ambrose of Milan

There are also other wars which the Christian wages, the struggles of different lusts, and the conflicts of the will; and domestic foes are far more dangerous than foreign.

Catena Aurea by Aquinas ↗

Gregory the Dialogist

Because the things which have been prophesied of arise not from the injustice of the inflictor of them, but from the deserts of the world which suffers them, the deeds or wicked men are foretold; as it is said, But before all these things, they shall lay their hands upon you: as if He says, First the hearts of men, afterwards the elements, shall be disturbed, that when the order of things is thrown into confusion, it may be plain from what retribution it arises. …

Catena Aurea by Aquinas ↗

Bede

But before all this, they will lay their hands on you, and persecute you, delivering you up to the synagogues and prisons, dragging you before kings and governors for my name's sake. This indeed had been either the sole or the greatest cause of ruin for the Jewish nation, because after the occasion of the Lord Savior, they likewise harassed his preachers and confessors with impious cruelty.

On the Gospel of Luke ↗