Ambrose of Milan

The two sentences seem to have a certain similarity, yet in that similarity there is a great difference. There is a difference in the way a person eats of the earth, as the serpent is related to have done and the manner in which this is recorded of the man: 'In sadness shall you eat.' That very phrase 'in sadness' makes the precise difference. Note how important this difference is. …

On Paradise, 15.75 ↗

Jerome

Cursed is the ground because of your actions. The works here do not refer to cultivating the land, as many think, but rather sins are signified. As it is written in Hebrew: And Aquila does not disagree, saying: Cursed is the soil because of you. And Theodotion: Cursed is the earth because of your transgression.

Hebrew Questions on Genesis ↗

Bede

But to Adam he said: Because you have listened to the voice of your wife and have eaten from the tree concerning which I commanded you not to eat, cursed is the ground because of you. In toil you shall eat of it all the days of your life, thorns and thistles it shall bring forth for you, and you shall eat the plants of the field, etc. Who is ignorant that these are the labors upon the earth of the human race, and that they would not be if the happiness that was in paradise had been maintained? …

Commentary on Genesis (Hexaemeron) ↗