Theophylact of Ohrid

Furthermore, as soon as anyone turns away from good, he immediately becomes useless. For vice is nothing other than a perversion of the natural impulses toward good; therefore, by driving a person toward what is contrary to nature, it renders him useless. For nature no longer makes use of him, just as it does not make use of those who are sick in the conduct of its affairs.

Commentary on Romans ↗

Thomas Aquinas

Then he removes the good works themselves. First, he cites offenses against the divine law when he says, all have turned out of the way, namely, from regulation by divine law: they have all turned to their own way (Isa 56:11). Second, failure to pursue the end; hence he adds, they have become unprofitable together. For we call unprofitable whatever does not attain its end. Therefore, when men turn from God for whom they were made, they are rendered unprofitable: the brood of the ungodly will be of no use (Wis 4:3). …

Commentary on Romans ↗

Bonaventure

The Scripture shut up all things under sin, the first through ignorance, the second through weakness, and the third through malice, so that when Christ came, He could have mercy on them all. And the Apostle wonders at this, and quotes the authority of the Psalm: "All alike have gone astray; they have become perverse; there is not one that does good, not even one."

Collations on the Hexaemeron, Collation 14 ↗