Cyril of Jerusalem

You have often heard also the words of the psalm: "To the dust of death you have brought me down." Think also of the prophecy of Jacob in the Scriptures: "He lay down and couched as a lion, and as a lion's whelp; who will disturb him?" Similarly in Numbers: "Lying down he has slept as a lion, and as a lion's whelp."

Catechetical Lecture 14:3 ↗

Augustine of Hippo

"I was poured out like water, and all My bones were scattered" [Psalm 22:14]. "I was poured out like water," when My persecutors fell: and through fear, the stays of My body, that is, the Church, My disciples were scattered from Me. [Matthew 26:56] "My heart became as melting wax, in the midst of my belly." My wisdom, which was written of Me in the sacred books, was, as if hard and shut up, not understood: but after that the fire of My Passion was applied, it was, as if melted, manifested, and entertained in the memory of My Church.

Exposition on Psalm 22 ↗

Thomas Aquinas

"Like." Next he sets forth the effect of the persecution. And first he proposes this effect. Second, he expounds it, at "Scattered." He says therefore: they persecute me and harm me, because as regards bodily health they have entirely prevailed. And therefore he says, "I am poured out like water." If oil is poured out, something remains in the vessel; if wine is poured out, at least the scent remains in the vessel; but of water nothing remains. As if to say: I am entirely poured out, according to their opinion: 2 Sam. …

Exposition on the Psalms of David ↗