Gregory of Nyssa

For wine newly drawn forth, evaporates on account of the natural heat in the liquor, throwing off from itself the scum by natural action. Such wine is the new covenant, which the old skins because of their unbelief contain not, and are therefore burst by the excellence of the doctrine, and cause the grace of the Spirit to flow in vain; because into an evil soul wisdom will not enter. (Sap. 1:4.)

Catena Aurea by Aquinas ↗

Augustine of Hippo

But the Apostles are compared to old skins, who are more easily burst with new wine, i. e. with spiritual precepts, than contain them. Hence it follows, Else the new wine will burst the skins, and the wine will be spilled. But they were new skins at that time, when after the ascension of the Lord they received the Holy Spirit, when from desire of His consolation they were renewed by prayer and hope. Hence it follows, But the new wine must be put into new bottles, and both are preserved.

Catena Aurea by Aquinas ↗

Ambrose of Milan

The weakness of man's condition is exposed when our bodies arc compared to the skins of dead animals.

Catena Aurea by Aquinas ↗

Bede

And no one puts new wine into old wineskins; otherwise, the new wine will burst the skins; it will be spilled, and the skins will be ruined. But new wine must be put into new skins, and both are preserved. He also compares them to old wineskins, which, with new wine—that is, spiritual precepts—would burst more easily than they could contain it. But they will be like new wineskins, when after the Lord's ascension, they are renewed with the desire for his consolation by praying and hoping. …

On the Gospel of Luke ↗