Cyril of Alexandria

To a purpose thus excellent, and a proportionate earnestness the Saviour bids us hold fast, thus saying; "In that day he who is upon the housetop, and his goods in the house, let him not go down to carry them away: and he who is in the field, let him in like manner not return back." He was speaking of the last day, that is, of the end of this world; for as it was, He said, in the days of Noah and Lot: they were eating, and drinking, and were taking wives, and being made the wives of men, until the flood came; and upon Sodom fire …

Commentary on the Gospel of Luke, Sermon 118 ↗

Theophylact of Ohrid

Matthew relates all these things to have been said by our Lord, with reference to the destruction of Jerusalem, that when the Romans came upon them, they who were on the housetop should not come down to take any thing, but fly at once, nor they that were in the field return home. And surely so it was at the taking of Jerusalem, and again will be at the coming of Antichrist, but much more at the completion of all things, when that intolerable destruction shall come. Next follows the promise, Whosoever shall seek, &c. …

Catena Aurea by Aquinas ↗

Cyprian

That those who are snatched from the jaws of the devil, and delivered from the snares of this world, ought not again to return to the world, lest they should lose the advantage of their withdrawal therefrom. In Exodus the Jewish people, prefigured as a shadow and image of us, when, with God for their guardian and avenger, they had escaped the most severe slavery of Pharaoh and of Egypt-that is, of the devil and the world-faithless and ungrateful in respect of God, murmur against Moses, looking back to the discomforts of the desert …

Treatise XI Exhortation to Martyrdom Addressed to Fortunatus ↗

Augustine of Hippo

For he is on the housetop who, departing from carnal things, breathes as it were the free air of a spiritual life. But the vessels in the house are the carnal senses, which many using to discover truth which is only taken in by the intellect, have entirely missed it. Let the spiritual man then beware, lest in the day of tribulation he again take pleasure in the carnal life which is fed by the bodily senses, and descend to take away this world's vessels. …

Catena Aurea by Aquinas ↗

Ambrose of Milan

"He that will be on the housetop, do not let him go down. He that will be in the field, do not let him turn back." How may I understand what is the field unless Jesus himself teaches me? He says, "No one putting his hand to the plough and looking back is fit for the kingdom of God." The lazy person sits in the farmhouse, but the industrious person plants in the field. The weak are at the fireplace, but the strong are at the plough. The smell of a field is good, because the smell of Jacob is the smell of a full field. …

Commentary on Luke ↗

Bede

In that hour, whoever is on the housetop, and his goods are in the house, let him not come down to take them away. So far it has been mentioned that the kingdom of God, that is Christ, will come not with observation, but unexpectedly; now it is shown by whom this same coming should be expected. Therefore, he is on the housetop who, exceeding the carnal, lives spiritually as if in free air. …

On the Gospel of Luke ↗