Cyril of Alexandria

He took thought for His mother, paying no heed to His own bitter agony, for His sufferings affected Him not. He gave her into the charge of the beloved disciple (this was John, the writer of this book), and bade him take her home, and regard her as a mother; and enjoined His own mother to regard him as none other than her true son----by his tenderness, that is, and affection, fulfilling and stepping into the place of Him, Who was her Son by nature. …

Commentary On The Gospel Of John 12 ↗

Theophylact of Ohrid

So this disciple took Mary to his own home, for the Pure One was entrusted to the pure one. See how the female sex is steadfast in troubles, while the men all abandoned the Lord. Truly He came who strengthens the weak and accepts the lowly.

Commentary on John ↗

Augustine of Hippo

But what was this "his own," unto which John took the mother of the Lord? For he was not outside the circle of those who said unto Him, "Lo, we have left all, and followed Thee." No, but on that same occasion he had also heard the words, Every one that hath forsaken these things for my sake, shall receive an hundred times as much in this world. That disciple, therefore, had an hundredfold more than he had cast away, whereunto to receive the mother of Him who had graciously bestowed it all. …

Tractates on John 119 ↗

Jerome

For we judge people's virtue not by their sex but by their character, and we hold those to be worthy of the highest glory who have renounced both rank and wealth. It was for this reason that Jesus loved the Evangelist John more than the other disciples. For John was of noble birth and known to the high priest, yet he was so little intimidated by the plotting of the Jews that he introduced Peter into his court and was the only one of the apostles bold enough to take his stand before the cross. …

Letter 127.5 ↗

Gregory the Dialogist

The virgin mother, when wine was lacking, wanted Jesus to do a miracle. She was at once answered, "Woman, what have I to do with you?" as if to say plainly, The fact that I can do a miracle comes to me from my Father, not my mother. For it was from the nature of his Father that he could do miracles but from the nature of his mother that he could die. …

Register of Epistles, Book 10, Epistle 39 ↗