Cyril of Alexandria

It seemed right to some of the previous exegetes to make this the head of the chapter that follows. For thus says the Lord: "In due season I heard you and on the day of salvation I helped you." And they say that this is what was said by the God and Father of all to Christ our Savior. For they weave in such a sense to the words. For he prayed, saying before the precious cross, "Father, if it is possible, take away this cup from me." But he was not heard, and he drank it. …

Commentary On Isaiah 4:4.49:10 ↗

Augustine of Hippo

Those who have faith by which they win justification attain by the grace of God to the law of justice. For this reason the prophet says, "In an acceptable time I have heard you, and in a day of salvation I have helped you."

Letter 186 ↗

Jerome

Thus says the Lord: In a time of favor I have answered you, and in a day of salvation I have helped you; I have kept you and given you as a covenant to the people, to establish the land, to apportion the desolate heritages; saying to the prisoners, 'Come out,' to those who are in darkness, 'Show yourselves.' They shall feed along the ways, on all bare heights shall be their pasture; they shall not hunger or thirst, neither scorching wind nor sun shall strike them down, for he who has pity on them will lead …

Commentary on Isaiah ↗

Thomas Aquinas

901. Another preamble to their liberation is the exaltation of the liberating king, namely, Cyrus: in an acceptable time, and he does not determine the time of his exaltation: acceptable, when it pleased me to save my people, I have heard you, exalting you into kingship, according to your desire; and the fruit of his exaltation: I have preserved you; to be a covenant fulfilled of my people. Or of Christ, who was despised in his passion and was judged like a servant, below: we have seen him . . . …

Commentary on Isaiah ↗