John Chrysostom

And Saul arose from the earth; and when his eyes were opened, he saw no man: but they led him by the hand, and brought him into Damascus-the spoils of the devil, his goods, as from some city, yea, some metropolis which has been taken. And the wonder of it is, the enemies and foes themselves brought him in, in the sight of all!

Homily on Acts 19 ↗

Ephrem the Syrian

And if any one should say, "Wherein did our Lord speak humbly with Paul? for lo! the eyes of Paul were grievously smitten;" let him know that it was not from our merciful Lord that this chastisement proceeded, who spoke those words in humility; but from the vehement light that vehemently shone forth there. And this light did not strike Paul by way of retribution on account of his deeds, but on account of the vehemence of its rays it hurt him, as he also said: When I arose, I could discern nothing for the glory of the light. …

Homily - On Our Lord ↗

Theophylact of Ohrid

"Saul arose from the ground, and with his eyes open he saw no one." Paul's eyes suffered because an excess of light ordinarily acts painfully, since the eyes too have a limit. They also say that an excessive sound makes one deaf and insensible.

Commentary on Acts ↗

Ambrose of Milan

Although he saw nothing when his eyes were opened, still he saw Christ. And it was fitting that he saw Christ present and also heard him speaking. That overshadowing is not the overshadowing of blindness by grace. Indeed, it is said to Mary, "The Holy Spirit shall come upon you, and the power of the Most High shall overshadow you."

On the Blessings of the Patriarchs ↗

Bede

And when his eyes were opened, he saw nothing. He could not see well again unless he was first properly blinded, and excluding his own confounding wisdom, would he commit himself to faith in all things.

Commentary on Acts ↗