John Chrysostom

"Who both killed the Lord," he says-but, perhaps, they did not know Him,-assuredly they did know Him. What then? Did they not slay and stone their own prophets, whose books even they carry about with them? And they did not do this for the sake of truth. There is therefore not only a consolation under the temptations, but they are reminded not to think that (the Jews) did it for the truth's sake, and be troubled on that account. "And drave out us," he says. And we also, he says, have suffered numberless evils. …

Homily on 1 Thessalonians 3 ↗

Theophylact of Ohrid

And what is surprising in that they mistreated their own countrymen, when they even killed the Lord? See what a consolation it is to be a partaker with Christ in sufferings! Therefore Paul also always points this out in trials. But someone will say that they did not recognize the Lord. So what? Did they not recognize their own prophets, whose books they carry everywhere? How then did they kill them too? From this it is evident that they do nothing as zealots for the truth, but rather rage against the truth. …

Commentary on 1 Thessalonians ↗

Thomas Aquinas

Then when Paul observes, who killed both the Lord Jesus, he rebukes the Jews who started the persecution. First, he recalls their sin, and then the reason for the sin (2:16). In regard to the first point Paul does three things: first, he treats their sin in relation to God's ministers; secondly, with reference to God Himself; and thirdly as relating to the entire human race. The ministers of God are those who preach, namely, Christ, the prophets and the apostles. …

Commentary on 1 Thessalonians ↗