Fathers

Genesis 4

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And Adam knew Eve his wife; and she conceived, and bare Cain, and said, I have gotten a man from the LORD. And she again bare his brother Abel. And Abel was a keeper of sheep, but Cain was a tiller of the ground. And in process of time it came to pass, that Cain brought of the fruit of the ground an offering unto the LORD. And Abel, he also brought of the firstlings of his flock and of the fat thereof. And the LORD had respect unto Abel and to his offering: But unto Cain and to his offering he had not respect. And Cain was very wroth, and his countenance fell. And the LORD said unto Cain, Why art thou wroth? and why is thy countenance fallen? If thou doest well, shalt thou not be accepted? and if thou doest not well, sin lieth at the door. And unto thee shall be his desire, and thou shalt rule over him. And Cain talked with Abel his brother: and it came to pass, when they were in the field, that Cain rose up against Abel his brother, and slew him. And the LORD said unto Cain, Where is Abel thy brother? And he said, I know not: Am I my brother's keeper? And he said, What hast thou done? the voice of thy brother's blood crieth unto me from the ground. And now art thou cursed from the earth, which hath opened her mouth to receive thy brother's blood from thy hand; When thou tillest the ground, it shall not henceforth yield unto thee her strength; a fugitive and a vagabond shalt thou be in the earth. And Cain said unto the LORD, My punishment is greater than I can bear. Behold, thou hast driven me out this day from the face of the earth; and from thy face shall I be hid; and I shall be a fugitive and a vagabond in the earth; and it shall come to pass, that every one that findeth me shall slay me. And the LORD said unto him, Therefore whosoever slayeth Cain, vengeance shall be taken on him sevenfold. And the LORD set a mark upon Cain, lest any finding him should kill him. And Cain went out from the presence of the LORD, and dwelt in the land of Nod, on the east of Eden. And Cain knew his wife; and she conceived, and bare Enoch: and he builded a city, and called the name of the city, after the name of his son, Enoch. And unto Enoch was born Irad: and Irad begat Mehujael: and Mehujael begat Methusael: and Methusael begat Lamech. And Lamech took unto him two wives: the name of the one was Adah, and the name of the other Zillah. And Adah bare Jabal: he was the father of such as dwell in tents, and of such as have cattle. And his brother's name was Jubal: he was the father of all such as handle the harp and organ. And Zillah, she also bare Tubal-cain, an instructer of every artificer in brass and iron: and the sister of Tubal-cain was Naamah. And Lamech said unto his wives, Adah and Zillah, Hear my voice; ye wives of Lamech, hearken unto my speech: for I have slain a man to my wounding, and a young man to my hurt. If Cain shall be avenged sevenfold, truly Lamech seventy and sevenfold. And Adam knew his wife again; and she bare a son, and called his name Seth: For God, said she, hath appointed me another seed instead of Abel, whom Cain slew. And to Seth, to him also there was born a son; and he called his name Enos: then began men to call upon the name of the LORD.

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What the Fathers say

Genesis 4:25

Eastern Fathers

Clement of Alexandria

We agree that weakness of will and sexual immorality are passions inspired by the devil. But the harmony of responsible marriage occupies a middle position. When there is self-control, it leads to prayer; when there is reverent bridal union, to childbearing. At any rate, there is a proper time for the breeding of children, and Scripture calls it knowledge, in the words "Adam knew his wife Eve, and she conceived and bore a son, and called him by the name of Seth, 'for God has raised up for me another child in Abel's place.' "

The Stromata Book 3 ↗

Cosmas Indicopleustes

And when she had conceived, she bare a son and called his name Sêth, for, said she, God hath raised me up another seed instead of Abel whom Cain slew; implying by this that Abel has died childless, and the seed of Cain is to perish; this hath God given me as a new foundation for the human race. So far Eve.

The Christian Topography, Book 5 ↗

Western Saints

Augustine of Hippo

It is quite possible that when Adam was divinely inspired to say, after Seth was born, "God has given me another seed, for Abel whom Cain slew," there is no implication here that Seth was the next born in the order of time but only that he was destined to be a fit heir in the order of holiness.

City of God 15.15 ↗

Jerome

And he called his name Seth. For God has provided me another offspring in place of Abel, whom Cain killed. Seth, properly θέσις, that is, position, is called because God had set him in place of Abel. Finally, Aquila says: And he called his name Seth, saying: For God has placed another offspring for me.

Hebrew Questions on Genesis ↗

Bede

And Adam knew his wife again, and she bore a son, and he called his name Seth, saying: God has appointed for me another offspring instead of Abel. After he mentioned the fratricide Cain being extinguished, and repeated that his progeny was cursed in the seventh generation, he returns to explain the restoration of the holy seed, and that this remained perpetually despite the perishing of the impious. Now Seth is interpreted as "appointed" or "resurrection," the reason for the name being revealed by the parent saying:

Commentary on Genesis (Hexaemeron) ↗